Incidence and risk factors for severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, and eclampsia at preterm and term gestation: a population-based study

BackgroundThe majority of previous studies on severe preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, low platelet count syndrome were hospital-based or included a relatively small number women. Large, population-based examining gestational age–specific incidence patterns risk factors for these pregnancy complications are lacking.ObjectiveThis study aimed to assess the rates syndrome, eclampsia.Study DesignWe carried out retrospective, cohort that all women with singleton hospital birth in Canada (excluding Quebec) from 2012 2016 (N=1,078,323). Data primary outcomes (ie, eclampsia) obtained delivery hospitalization records abstracted by Canadian Institute Health Information. A Cox regression was used independent (eg, maternal age chronic comorbidity) each outcome differences effects at preterm vs term gestation (<37 ?37 weeks).ResultsThe preeclampsia (n=2533), (n=2663), eclampsia (n=465) 2.35, 2.47, 0.43 per 1000 pregnancies, respectively. The cumulative term-onset lower than preterm-onset (0.87 1.54 1000; rate ratio, 0.57; 95% confidence intervals, 0.53–0.62), similar (1.32 1.23 0.93; interval, 0.86–1.00), (0.12 0.33 2.64; 2.16–3.23). For outcome, comorbidity congenital anomalies stronger preterm- disease. Younger mothers (aged <25 years) higher ages, whereas older ?35 had risks syndrome. Regardless age, nulliparity factor outcomes, socioeconomic status inversely associated preeclampsia.ConclusionThe declined term, increased gestation. Young an preeclampsia. Prepregnancy fetal more strongly lacking. This eclampsia. We weeks).